Severe Acute Respiratory Coronavirus-2: A Critical Review of Virus Biology, Genome and Pathophysiology

Severe Acute Respiratory Coronavirus-2 [SARS-CoV-2] emerged as a great threat to the world at end of December 2019 in China. The SARS-CoV-2 evolved from virus responsible for SARS epidemic 2002. has high rate human-human transmission and originated bat. It close resemblance with bat-like-SARS-CoV compared SARS-CoV; however, Spike protein virus-host cell interaction possesses least similarity that SARS-CoV. Cytokine Storm is associated severity Covid-19 leads acute respiratory distress syndrome [ARDS] and/or multiple organ dysfunction syndromes [MODS]. In current review article, features novel coronavirus, including viral biology, genomic organisation, life cycle, pathophysiology genetic diversity, have been discussed. development policies plans which can prepare future pandemics also proposed. addition, drug pipelines, diagnostic facilities management such need an up-gradation contain well outbreaks.